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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

May the beauty and joy of New Year remain with you throughout the new year!愿新春美景与欢乐常伴随你!
In October last year North Korean border guards attempted to shoot down some balloons, triggering a brief exchange of heavy machine-gun fire between the two sides.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

In those days, of course, Rembrandt was the gold standard. But the Dutchman and his fellow old masters have fallen out of fashion and are no longer as coveted by collectors and investors.
简言之,无叶风扇就是没有叶片的风扇。它的工作原理是先将空气吸入风扇基座内部,然后通过扇头环形上的洞将空气吹出。这款风扇据说是詹姆斯·戴森发明的,并命名为"气流倍增器"。就像可以飞行的喷气背包一样,无叶风扇被《时代周刊》评为"2009年度伟大发明"之一,同样它也不是世界上第一个无叶风扇。实际上,第一个无叶风扇于1981年被日本的东京芝区电力公司获得专利。尽管东京芝区电力公司的无叶风扇并没有用于生产制造,但詹姆斯的无叶风扇的原始设计与其设计相似,所以专利局拒绝授予詹姆斯这个专利。尽管授予东京芝区电力公司的专利已经过期,但在授予詹姆斯这项新专利之前,专利局需要他提供该设计的创新之处。詹姆斯的经理吉尔·斯密斯并没有否认这两种无叶风扇间的相似性,只是说两者间的差异在于所用"科技"不同。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

regulate

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The US and European steel industries have accused China’s heavily subsidised sector of flooding the global market with steel, “dumping” it by selling below production costs and driving down international prices. The collapse in steel prices in recent years has caused the closure of mills across the world from Australia to the UK and parts of the US industrial heartland.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Manufacturing has held up better, with profits growing 6.5 per cent, while profits from utilities such as electricity, heat and water grew 17 per cent, boosted by lower energy prices.
权且称之为“白”的危机。
这张专辑等于是一次直截了当的暗示,提醒着我们,不论什么时候,只要霉女王想要,她就能拿回自己在流行音乐界的领先地位。
China has become the world's largest industrial robot market since 2013, and currently its domestic suppliers are moving up the supplier chain by offering more high-end products in recent years, added the report.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 楼市调控“长效机制”雏形确立
Perspective

Trends and targets in antiviral phototherapy

5、低效的邮件沟通
单词distract 联想记忆:
"While most Chinese brands remain unknown to the outside world, within China they are establishing themselves with ever more sophisticated campaigns," said Rupert Hoogewerf, Hurun Report chairman and chief researcher.
不过,从乐观角度看,阻碍复苏的几个拦路虎──身负重债的消费者、半死不活的楼市和心有余悸的银行──已经不再对招聘造成负面影响。除非经济受到意外的打击,否则这可能意味着2013年将又是一个缓慢但稳定的增长之年。[qh]

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 迎接2.0时代绿建行业整装待发
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

11月,由财新网(Caixin)赞助的中国制造业采购经理人指数(PMI)初值为48.6,高于预期的48.3。而10月份该读数则为48.3。读数显示上个月中国制造业活动在继续放缓,不过情况没有10月份那么糟糕。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

And, ‘trustno1’ proved, perhaps unsurprisingly, to be among the worst passwords as well, taking up spot number 25.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

佳士得珠宝部门的国际高级鉴定师吉恩马克·鲁纳尔称:“这颗钻石完美无瑕,从内到外都绝对纯净。”
3.《初恋50次》

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

All three of the big worldwide financial bubbles that have blow up in the last three decades have 'been fueled by the Fed keeping policy rates below the nominal growth rate of the economy far too long, ' says global strategist Kit Juckes of the French bank Societe Generale.
"Another interesting aspect of this year's list is that more short numerical passwords showed up even though websites are starting to enforce stronger password policies."

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

It is a struggle for power contained by understandings and institutions.
Every great detective needs his or her definitive story. For Sherlock Holmes it was The Hound of the Baskervilles. For Agatha Christie’s fussy Belgian sleuth Hercule Poirot it’s Murder on the Orient Express – a tale in which a bloodthirsty villain kills a wealthy businessman during a train journey through the Balkans. Or are things really what they seem? Sidney Lumet made a beloved film out of the story in 1974, with a stunning cast that included Sean Connery, Ingrid Bergman and Albert Finney as Poirot. Now Kenneth Branagh is donning the Belgian’s moustache himself, as well as stepping behind the camera as director, in his glossy new big-screen version, starring Johnny Depp, Daisy Ridley, Michelle Pfeiffer, Penelope Cruz and Dame Judi Dench. Is there something new that can be mined from this story? Maybe. But even if not, Christie fans will surely want to climb aboard. Released November 3 in the UK, November 10 in the US, China and Turkey, and November 30 in China's Hong Kong and Singapore. (Credit: 20th Century Fox)

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

greenhouse
This move works on multiple fronts for the Thunder. First, Gibson helps fill in for the injured Enes Kanter in the short-term and he brings playoff experience, solid rebounding and hard-nosed defense to a possible postseason matchup with the Spurs or Rockets.
7.思想控制仿生腿
Hua Xu Yin

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

The Bellarine Peninsula, located Southwest of Melbourne, Victoria, has been a hotspot for timeless beaches and historic towns like Queenscliff and Portarlington.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

当你和他/她在一起的时候,你看不见周围的所有人,你的眼中只有他/她
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

2、《蝙蝠侠大战超人:正义黎明》

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

试图推动亚洲ETF持续繁荣但迄今未获成功的公司表示,有必要从根本上改革似乎表明,市场将由说服监管机构和客户重塑行业格局的长期努力定义。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

《财富》美国500强公司苹果(Apple))已宣布,将从现金中拿出300亿美元用于股票回购。这个消息让投资者很高兴:股价暴涨,甚至在消息发布一周后,这只股票相对于标准普尔指数在这7天上涨了12%。苹果有一项规模更大、总额高达1300亿美元的资本回报计划,将一直延续到2015年,而这些回购就是这项计划的一部分。
毫无疑问,全世界的肠胃病学家都会感谢Emmanuel Ben-Soussan和Michel Antonietti,因为他们的研究给出了医生该如何进行结肠镜检查的推荐,从而让他们的病人发生气体爆炸的可能性降至最低。
About 980 million yuan of illicit assets were recovered, according to the Communist Party of China Central Commission for Discipline Inspection.
与无锡接近的涨幅第二的城市是湖南省省会长沙,该市环比涨幅为4.5%。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

7. MonPère
3.Porto, Portugal
[p?n'demik]
Box office sales in the world's second largest film market have posted average growth of 35 percent year on year since 2003. In 2015 alone, it grew a whopping 48.7 percent, according to the State Administration of Press, Publication, Radio, Film and Television (SARFT).
n. 三角(形)

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 首批老人入住共有产权养老社区
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

美国演员、作家、时装设计师、舞蹈演员、制片人、歌手——拥有这么多头衔的珍妮弗·洛佩兹是2015年全球十大美女的亚军。作为一个结过三次婚的女星,洛佩兹的感情问题一直都是世界各国媒体关注的焦点。除涉足娱乐圈外,她还在商业领域颇有建树,其中包括经营服装、配饰、香水等。此外,她拥有一家制片公司,主持电视节目,还成立了一家慈善机构。
Company: The Grommet

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

该书反映了部分群体越来越担忧自动化可能对就业——从制造业到专业服务领域的就业——产生的负面影响。该书英国版的副标题警告了“大规模失业的威胁”,美国版的副标题则预言了“一个失业的未来”。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Tsinghua University holds the No. 1 spot in both computer science and engineering. The Chinese institution overtook MIT for the top computer science rank this year.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

面对批评,梅耶尔4月份接受本刊采访时为自己的决定进行了辩解,她说人们“错误地把这项措施视为行业条例。”她表示,自己需要员工在办公室工作,目的是鼓励他们进行合作与创新。目前看来,这个不同寻常的做法可能正在对雅虎产生积极影响——2012年梅耶尔上任以来,这家公司的股价已经上涨了一倍多。
It will be interesting to see which direction they go at the trade deadline. They have a handful of solid players along with Brook Lopez.
目前已经被泄露的照片多达10个G。据《北京日报》12月1日报道,著名在线P2P借贷平台"借贷宝"也和此次事件有关。
8. Trang Islands, Thailand-The islands of Trang, a sleepy province in southeast Thailand, have remained under the radar. Wooden longtail boats can be rented to travel between the islands—and to see the endangered dugongs.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

优秀的老板们懂得授权的艺术。我的一位评论家说要沿着线走“他们已经从目前的工作里面抽身”,意味着他们不干涉每一天和每一分的工作流程和程序。本质上,学着去授权给员工去代替微化管理是对员工的一种信任。
你感到抓狂是对的。公司无时无刻不在监视着你。无论你做什么都有记录:你打的每个电话,发的每条短信,每条在推特上发的帖子和讯息。在大部分公司,这些记录可永远不会删除(这吓人的吧,真可怕~)
A lot of the best James Bond theme songs sound like they belong in a lounge act. That's not a complaint, just an observation. For whatever reason, the English new wave act Duran Duran was given free reign to provide A View to a Kill with a new and exciting sound all its own. "A View to a Kill" was a hit song, and it probably would have been a success even without the James Bond connection. It's entertaining and cool and energetic, and it promises one hell of a good time. (Whether or not the movie actually lives up to that promise is a matter of some debate.)
The emotions were far more visceral and less attractive.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

n. 火焰,热情
Coke's Kent is not the only chief executive who spoke out in 2013 about the merits of immigration reform for big business.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

该办公室预计今年足球学校的数量将增加到20000所,到2025年时将增加到50000所。
2014年,尽管汽车销量自2007年以来首次超过1600万辆,但占据媒体头条的还是各类召回事故。在召回舞台上最活跃的是通用汽车公司,由于不断曝出点火开关故障,通用今年已经召回了几百万辆汽车。这家汽车制造商选择勇敢曝光自己的失误,并公开发布了一份自查报告。而日本气囊生产商高田公司却对“气囊门”三缄其口,转而把补救措施留给其深陷困境的客户本田和丰田来实施。有问题的气囊爆炸后,会向驾驶室弹出致命碎片。
A meditation on love, loss and the meaning of life. Dog people and Lou Reed fans will be especially susceptible (I plead guilty on both counts), but anyone who ever had a heart is likely to succumb to Ms. Anderson’s ethereal wisdom and her fierce formal wit.
New York's inactivity begs two questions. Does Jackson have the energy needed to undo the damage he's created during his tenure?
8. The 2012 Ig Nobel Fluid Dynamics Prize

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

上班迟到,休息后又迟回工作岗位表现出来的是一种傲慢、随便的工作态度。 因此,快速或者甚至是稍微提前一点进入工作状态说明你有时间观念,你确实很在乎工作和别人时间。
他会在自己的独唱专辑中尝试什么样的歌曲呢:《Sweet Creature》(《可爱的人儿》)和《Ever Since New York》(《自从来到纽约》)是温馨的原声抒情歌曲;而在《Kiwi》(《奇异果》)这首歌中,他大声地炫耀着自己的欢乐;《Two Ghosts》(《两只幽灵》)则是一首为分手而惋惜的歌曲。
n. 平台,站台,月台,讲台,(政党的)政纲

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Nigel Farage, former leader of the UK Independence party, has not advanced so far because it has proved harder to capture the UK’s party-based institutions than it is the US presidency.
30岁的阿什莉·格林汉姆是首位跻身收入榜单的大码模特,她通过自己的内衣和泳衣品牌代言合同赚得550万美元,排在榜单的第十位。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

mod风度+est→做事有风度→礼貌的,谦虚的
如果一并考虑过去几天里公布的数据,情况也不会变得更好。上个月,日本仍在与通缩和家庭开支下滑作斗争。不过,今天早上公布的零售业销售数据超出了人们的估计。
TAXES: Approximately $18,036 a year

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The writer is a senior associate at the Carnegie Endowment and a former World Bank country director for China. Read other predictions for the world economy, politics and finance in 2012 at www.ft.com/thealist
Goldman Sachs will pay out big bonuses, be publicly vilified for a month and then go quietly back to printing profits.
美国电影学会年度电影奖

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

鲁拉卡拉夫(Roula Khalaf)

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

萝丝王在中国长大,在那里学会了计算机编程。大学毕业后,她希望到美国工作。第二年,《中国学生保护法案》(Chinese Students Protection Act)获得通过,萝丝王获得了休斯敦大学的计算机科学硕士学位。2001年9月11日之前,她曾在多家硅谷初创公司(包括成立自己的公司iBizWomen.com)工作。911事件让她产生了创办Binary Group的想法。Binary Group是一家与联邦政府合作的科技咨询公司。过去16年间,这家公司帮助客户节省的资金不计其数——比如美军第20支援司令部(Army 20th Support Command)就在五年时间内共节省了6,000万美元卫星通信带宽开支。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

但近2/3(65%)的福音派白人新教徒认为这些暴风雨是“末日”即将到来的证据,就如《圣经》中预言的那样。
Guangzhou and Shenzhen, benefiting from balanced development, took first and second place respectively in the rankings. Hangzhou ranked third, owing to its technological advantages. Wuhan, which had achieved a good balance between development and costs, was in fourth place, followed by Nanjing with its quality culture and lifestyle.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

新近成立的Eleven James正在男表领域引入合作消费的概念。该公司的会员项目能令你获得亲近一系列精挑细选的高端腕表的机会,这一曾经只和私人飞机、豪华汽车及度假屋联系在一起的会员模式正在Eleven James的手中发扬光大。除腕表外,会员还能注册专享忠诚度项目,其中包括礼宾服务、合伙人利益专享及诸如腕表主题活动等独一无二的体验。听起来有点像男士腕表和飞机租赁公司Net Jets体验的大碰撞?公司创始人兰迪?布兰多夫(Randy Brandoff)在奢侈品营销领域拥有深厚经验,曾经在Net Jets担任高级副总裁和首席营销官、在Marquis Jets担任过执行副总裁和首席营销官。他的专长,加上年复一年增长势头良好的腕表行业,以及一种在其他市场证明行之有效的商业模式——看起来Elven James正是在恰当的时间叩开了市场的大门。
1=somewhat false
谎言6:我29岁。说谎原因:29岁听起来比30岁要年轻多了。
You've usually stated in pastinterviews that you have connections to your characters. In Aldnoah Zero, whichis currently airing, what do you think is your connection to Inaho?

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Yet when October was taken as a whole, only Shenzhen showed a real month-on-month price fall.
4. No talking during the game, wait for half-time or end of the game.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

美国公司高管的薪酬不断上升,收入差距越拉越大。在这种情况下,看到一位不光关心自身收入的CEO不禁让人眼前一亮。9月份,联想首席执行官杨元庆宣布,他将连续第二年和大约1万名联想员工分享他的奖金,数额至少为300万美元。他做出这个慷慨决定的原因是这家个人电脑制造商的年度销售额创下了历史新高。据彭博新闻(Bloomberg News)报道,参与“分成”的联想员工获得的奖金大约相当于中国普通城镇就业者一个月的收入。
"Last year, 1.2 million Chinese visited Australia. We anticipate this will grow during the China-Australia Year of Tourism and will continue to grow afterward."

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 门窗业进入设计“井喷时代”
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

这会吓走一些人,这些人不了解你更好。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Chazelle’s musical was the hot favourite going into the evening, with a record-tying 14 nominations. Chazelle won the best director award, while Emma Stone won best actress for her performance in the film, which was produced by Lionsgate. There were other La La Land Oscars for score and best original song.
temporary
你可能已经在使用谷歌日历了,但你使用的方式是否正确呢?告诉你一个秘诀:只要把在那个日子和那个时候会真正发生的事情记录在谷歌日历上就行。同时利用iPhone提醒记住那些时间敏感性不太强的事情(即不是那些精确到小时和分钟的事情)。遵循这一战略有助于你保持更清醒的状态。
布朗克斯大广场区或皇后区埃尔姆赫斯特(Elmhurst)的业主们,即将迎来急于寻找下一个未开发市场的买家们的新关注。“你什么时候听到别人谈论过布朗克斯的金斯布里奇(Kingsbridge)?”霍尔斯特德房地产公司的拉米雷斯问,“聪明人正在涌向那里,以实惠的价格买下房子。”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

The letter surfaced in a Pennsylvanian university mailroom earlier this month.
Chinese tourism to South Korea has boomed in recent years, delighting retailers but irking domestic tourists who have found the country’s attractions swamped with visitors.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

“Only once before, in 1998, has the new record been greater than the old record by this much,” the administration added.
[plein]
Rihanna vs. Rosario Dawson Both stars wore this long satin Dolce & Gabanna dress in different colors.   蕾哈娜和罗莎里奥·道森都穿了这件款式一致颜色不同的D&G

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

税:2014年约为16866美元(约合人民币10.8万元)
Rogers, unhappy with the turn of events, decided to leave the show after the first three seasons. The breach of contract led to a multi-million dollar lawsuit. Ironically, Wayne Rogers had never signed his contract to begin with (he had a problem with a morals clause). The lawsuit was thrown out. You could say Rogers got the last laugh, but since M·A·S·H went on for eight more seasons and Rogers' never reached the same career success again, the last laugh might be a relative concept.
达成一个全球性气候协议的下一次大尝试,将是在来自世界各地的谈判代表今年12月聚集巴黎的时候。气候变化问题的政治活动人士上周五不失时机地引用2014年的温度记录为证,表明采取强有力行动的必要性。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

连平说道:“在2017年的低基准上,今年CPI可能会以一个更快的速度上涨,但在需求稳定、货币环境紧张的背景下,不会出现明显的通胀压力。”
[kru:]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

“他不在情报系统监视范围内,”总理补充道。
1. Bubble With No Name Yet triggers the biggest crash in 30 years
The four megalopolises also saw fewer traffic jams after November due to reasons ranging from less travel in winter and smoggy days to the return of migrant workers to their hometowns.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

UK schools account for more than a third of all graduates from the top 50 pre-experience programmes and not only attracted nearly half of all female students but also almost half of all international students. Indeed, 94 per cent of students enrolled in a UK MiF pre-experience programme in 2014 were from overseas. About 85 per cent of these students were from outside the European Economic Area, including 55 per cent of the overall number from mainland China.
[k?n'denst]

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Haub School of Business at Saint Joseph’s University in Pennsylvania is the only school ranked for the first time, in 98th place.
The local court gave Zhou a lenient sentence due to the teenager's age and frank confession of the crime, according to the report.
读:奔腾。奔腾的特长就是永远有一颗奔腾的芯。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

“有个员工在公司网站上发帖称自己辞职了。”

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Since its first release in 1995, many new versions and sequels have been created. However, fans say none could replace the breath-taking and tragic tale of the original.
Her piece, titled “Back to Mother Nature," depicts an elaborate water-cleaning machine. Zhang worked with a team of artists at Google to animate her drawing.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

gala=milk牛奶,milky way=银河系以xy结尾的只有4个单词,xy表示交织在一起,象坐标线一样,银河系也象星星交织在一起。参:neodoxy(n 新学说;新见解);orthodoxy(adj 正统的);heterodoxy(n 非正统;异说)
In an effort to protect China's role in the global economy as a manufacturing hub, the central bank devalued the currency in August, in the biggest drop in decades. Later in the year, after the International Monetary Fund added the renminbi to its group of global reserve currencies, the value of the currency fell further, possibly reflecting capital outflows.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 木林森参股开发晶的两大“猜想”
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 看不动产证 还要看查册表
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

adj. 易坏的,脆弱的,浅薄的 n. 复写纸,薄纸副本
特约专栏作家安东尼·盖尔恩是Paragon欧洲合作伙伴的常务董事。目前位于伦敦。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Harry Potter fans, it's time for another movie. A prequel to the Harry Potter films, Fantastic Beasts and Where to Find Them follows the adventures of Newt Scamander in an ancient New York. It is based on the Hogwarts textbook in Harry Potter by the same name.
上榜理由:食物、文化和恐怖故事

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 规范民宿应多一些“网约”思维
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Such claims are unlikely to go away, though. John R. Christy, an atmospheric scientist at the University of Alabama in Huntsville who is known for his skepticism about the seriousness of global warming, pointed out in an interview that 2014 had surpassed the other record-warm years by only a few hundredths of a degree, well within the error margin of global temperature measurements. “Since the end of the 20th century, the temperature hasn’t done much,” Dr. Christy said. “It’s on this kind of warmish plateau.”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Chinese tech giant Lenovo, however, remained at the top of the market - owning more than 20% of it. HP followed in second place, with Dell third and Apple and ASUS tied for the fourth spot.
More importantly, their inventions may even eventually be turned into products that benefit mankind.
The ranking measures the quality and breadth of the schools’ postgraduate programmes. Schools must take part in all four rankings to be eligible for a full score. LBS rose from third last year by participating in all four rankings for the first time.
单词entertainment 联想记忆:

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

It’s the time of the year for list making! This Youku video clip named the nine hottest lines on China’s web this year. The Yangtze Evening Post, an influential newspaper, is the original list compiler.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 刚需族买房 资金实力也要杠杠的
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

That was a less marked jump than the 3 percentage point rise from August to September, however, suggesting recent curbs to property purchases may be having some effect.
JM Family Enterprises
They should be. We agree on that.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Prof Cusumano sees all this as evidence that the company is opening up more, including in allowing developers to customise more of its iOS software.
糟糕的婚姻会导致早逝

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

We've had the technology to artificially restore hearing for decades, but internal implants do nothing for the visible parts of the ear. You'd think those big flaps (“pinnae”) on either side of your head would be easy to replicate, since they're just skin and cartilage rather than complex organs. In reality, scientists have never done a good job with fake ears. Traditional replacements look and feel like plastic toys.
D'Aloisio himself strives to maintain a bubble of normalcy. He dates the same girl he did before the whirlwind hit. And though he's stopped attending school-he's too busy to sit in class while overseeing Summly's development-he still gets his work from his teachers and meets with them regularly. He cherishes the fact that his circle of friends knows little of his life as a budding industrialist. When I met him, he was about to head to Greece for a weeklong vacation with a pack of high school pals.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

It's important to remember that even when the overall number of jobs goes down, some companies are still adding workers -- it's just that others are cutting even more.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

在经济大幅放缓和复苏不顺的过程中,美联储的计划几乎都没有按照原先设定的那样去实施,美联储官员们现在也公开承认了这一事实。美联储主席贝南克(Ben Bernanke)上个月在其最后一次新闻发布会上表示,美联储对于增长步伐感到失望,同时也没有完全弄明白其中的原因。
排名第一的项目:清华-欧洲工商管理学院EMBA
本周一的谷歌首页涂鸦看起来十分意想天开,但关注却是一个非常严肃的问题:净水。该作品出自一名来自纽约长岛的11岁孩子之手,相当不错。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 东莞住宅供应量降至年内低点
Paper

Length-scale dependence of protein hydration-shell density

《暮光之城》众星前照令人大跌眼镜
自从2008年智能手机应用商店开始运营以来,达洛伊西奥就着手设计iPhone手机应用软件。那时12岁的他住在伦敦的温布尔顿,用卧室里的Mac电脑来工作。因为年纪太小,他在填写苹果(Apple)开发执照申请时用的都是他爸爸的名字。这之前他没在学校受过正式的电脑培训,他的父母(一个是律师,一个是商界管理人士)也都不从事技术行业工作。他几乎是完全靠刷网页、看教程来自学编程的。
17 November
这个belty运用现代科技追踪健康状况,水的摄入量,和动作,但你要花395美元,可能更值得买一个时尚的智能手表或运动手环。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

贷款的条件不仅仅只局限于裸照。同样被泄露的还有大量疑似借贷双方对话的屏幕截图,一个贷款人要求女学生提供自己的自慰视频。
3. 丹·韦斯(Dan Weiss),《14》,Pi Recordings。《14》的内容如此丰富,整张专辑的作曲由鼓手丹·韦斯一手包办:细节丰富的室内乐,前卫的啸叫,新音乐无词人声与北印度音乐。相比这个宏大的音乐参照系,更令人印象深刻的是,韦斯集结了12名同行乐手,把所有音乐元素融汇为流畅的整体。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Tiger got to hunt, bird got to fly;
根据中国国家统计局的数据,10月份中国规模以上工业增加值同比增长6.1%,与9月份的增幅一致,略低于经济学家的预期中值6.2%。
No matter what the inherent method of momentum, all of these engines leverage the latest engine technology to maximize both their power and fuel economy, and run the gamut from the tiny and efficient 1.0-liter turbocharged three-cylinder unit offered in the Ford Fiesta to the Chevrolet Corvette Stingray’s mammoth 6.2-liter V8 that proves there’s no substitute for sheer displacement. We’re featuring Wards’ 10 Best Engines in the accompanying slideshow.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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n. 喜剧,滑稽,幽默事件
China's expenditure on technology research and development rose 10.6% to 1.57 trillion yuan in 2016, the fastest annual growth since 2014, as the nation increases its investment in new driving forces to stabilize the economy.

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